Fatty acid homeostasis

Across TCGA patient cohorts, RNA activity of the Fatty acid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAA2, ERBB4, and KIF3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid homeostasis activity versus PRKAA2 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKAA2 →	+1.206	+0.293	<.001	<.001	3	4
CCRCC	ERBB4 →	+0.579	+0.214	<.001	.004	3	3
COAD	KIF3B →	+0.434	+0.433	.002	.008	3	3
BRCA	HCAR1 →	+1.060	+0.310	.006	.001	3	3
COAD	ABCC2 →	+0.904	+0.438	.001	.005	3	3
UCEC	DZIP3 →	-0.447	-0.137	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055089 vs PRKAA2 — BRCA

Explore this scatter interactively →