Fatty acid homeostasis

Across TCGA patient cohorts, RNA activity of the Fatty acid homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGA_S297, ALDOB, and HERC1_S2747, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid homeostasis activity versus FGA_S297 in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FGA_S297 →	+1.144	+0.458	<.001	<.001	3	3
PDAC	ALDOB →	-1.177	-0.304	<.001	<.001	3	3
OV	HERC1_S2747 →	+1.569	+0.350	<.001	.002	3	3
OV	PRR12_S1925 →	-1.183	-0.248	<.001	<.001	3	3
OV	PRRC2B_S226 →	+0.615	+0.212	.003	.001	3	3
OV	ATP5MF →	+0.631	+0.222	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055089 vs FGA_S297 — CCRCC

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