Fatty acid homeostasis

Across TCGA cell cohorts, RNA activity of the Fatty acid homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFMID, FAM20C, and ACSL4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFMID grouped by Fatty acid homeostasis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AFMID →	+0.636	+0.295	.003	<.001	3	4
OVARY	FAM20C →	-2.699	-1.248	.001	.002	3	4
LUNG_NSCLC_LUAD	ACSL4 →	-0.971	-0.433	<.001	.001	3	4
SKIN	FAM126A →	-0.802	-0.729	.008	.005	3	4
LUNG_SCLC	GLTPD2 →	+0.791	+0.262	.001	.004	3	4
LARGE_INTESTINE	ARMC2 →	+0.712	+0.311	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFMID by Fatty acid homeostasis activity — LARGE_INTESTINE

Explore this box plot interactively →