Fatty acid homeostasis

Across TCGA cell cohorts, RNA activity of the Fatty acid homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2L6, UBE2I, and TBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2L6 grouped by Fatty acid homeostasis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UBE2L6 →	-0.243	-1.669	.008	<.001	3	4
BLOOD_Leukemia	UBE2I →	+0.360	+0.324	.003	<.001	3	3
BLOOD_Leukemia	TBP →	-0.159	-0.230	.001	.001	3	3
BLOOD_Leukemia	SOX17 →	+0.360	+0.294	<.001	.001	3	3
BREAST	SAE1 →	+0.345	+0.174	<.001	.004	3	3
BLOOD_Leukemia	FDFT1 →	+0.237	+0.181	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2L6 by Fatty acid homeostasis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →