Monoatomic anion homeostasis

Across TCGA patient cohorts, RNA activity of the Monoatomic anion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIPR1, ABCD3, and SLC44A4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monoatomic anion homeostasis activity versus VIPR1 in PDAC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIPR1 →	+0.531	+0.618	.001	.006	3	5
PDAC	ABCD3 →	+0.225	+0.489	.007	.005	3	4
PDAC	SLC44A4 →	+0.855	+0.741	<.001	<.001	3	4
BRCA	CNNM4 →	+0.530	+0.580	.003	.003	3	4
OV	THSD4 →	+1.534	+0.850	<.001	<.001	3	4
LSCC	MAGI3 →	+0.447	+0.705	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055081 vs VIPR1 — PDAC

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