Copper ion homeostasis

Across TCGA patient cohorts, RNA activity of the Copper ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCA2, IDNK, and C11orf54, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion homeostasis activity versus CLCA2 in COAD (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CLCA2 →	+0.592	+0.243	.003	<.001	3	5
CCRCC	IDNK →	-0.527	-0.234	<.001	.002	3	4
CCRCC	C11orf54 →	-0.589	-0.172	.001	<.001	3	4
COAD	KLHL31 →	-0.374	-0.170	.006	.001	3	3
HNSC	KPNA4P1 →	-0.440	-0.106	<.001	<.001	3	3
OV	SHMT1 →	-0.652	-0.183	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055070 vs CLCA2 — COAD

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