Asymmetric neuroblast division

Across TCGA patient cohorts, RNA activity of the Asymmetric neuroblast division pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_S363, CSE1L, and DOCK7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric neuroblast division activity versus SYNPO2_S363 in PDAC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SYNPO2_S363 →	-1.022	-0.061	<.001	<.001	3	6
BRCA	CSE1L →	+0.282	+0.046	.002	.009	3	6
HNSC	DOCK7 →	+0.284	+0.099	<.001	<.001	3	6
HNSC	HSPB8 →	-0.741	-0.072	.001	.001	3	6
PDAC	CD34 →	-0.551	-0.055	<.001	<.001	3	5
HNSC	DSG2 →	+0.420	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055059 vs SYNPO2_S363 — PDAC

Explore this scatter interactively →