Asymmetric neuroblast division

Across TCGA patient cohorts, RNA activity of the Asymmetric neuroblast division pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSR2, RNU5E-10P, and TIGAR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Asymmetric neuroblast division activity versus SSR2 in LUAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SSR2 →	+0.454	+0.322	<.001	.001	3	4
COAD	RNU5E-10P →	+0.470	+0.570	.003	.002	3	4
COAD	TIGAR →	+0.280	+0.454	.003	.006	3	4
BRCA	CECR7 →	+0.954	+0.281	<.001	.003	3	4
UCEC	TAF11 →	+0.412	+0.378	.003	<.001	3	4
GBM	PRELID3B →	+0.484	+0.222	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055059 vs SSR2 — LUAD

Explore this scatter interactively →