Regulation of cardiac muscle tissue development

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DES, SGCA, and MIR1-1HG-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle tissue development activity versus DES in HNSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DES →	+2.558	+0.795	<.001	<.001	3	6
HNSC	SGCA →	+1.467	+1.067	<.001	<.001	3	5
HNSC	MIR1-1HG-AS1 →	+0.460	+1.060	<.001	<.001	3	5
HNSC	LINC00702 →	+0.704	+1.126	<.001	<.001	3	5
UCEC	RSPO3 →	+1.219	+0.743	<.001	<.001	3	5
COAD	COLEC12 →	+0.747	+0.684	.001	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055024 vs DES — HNSC

Explore this scatter interactively →