Atrial cardiac muscle tissue morphogenesis

Across TCGA patient cohorts, RNA activity of the Atrial cardiac muscle tissue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROX1, PROX1-AS1, and NR2F2-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial cardiac muscle tissue morphogenesis activity versus PROX1 in LSCC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PROX1 →	+1.082	+0.959	<.001	<.001	3	6
GBM	PROX1-AS1 →	+0.585	+0.707	<.001	<.001	3	5
HNSC	NR2F2-AS1 →	+0.366	+0.501	.004	.003	3	4
BRCA	SORBS1 →	+1.130	+0.654	.001	.005	3	4
BRCA	RASGRF2 →	+0.821	+0.611	.003	.004	3	4
BRCA	STARD9 →	+0.478	+0.631	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055009 vs PROX1 — LSCC

Explore this scatter interactively →