Atrial cardiac muscle tissue morphogenesis

Across TCGA cell cohorts, RNA activity of the Atrial cardiac muscle tissue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIPIN, PRR5L, and THNSL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIPIN grouped by Atrial cardiac muscle tissue morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TIPIN →	+0.734	+1.806	.005	<.001	3	5
KIDNEY	PRR5L →	-1.714	-1.111	.001	.009	2	5
PANCREAS	THNSL2 →	-1.968	-0.910	.001	.004	3	4
LUNG_SCLC	PARK7 →	-0.792	-1.225	.005	.002	3	4
URINARY_TRACT	ACOT7 →	-1.235	-1.518	<.001	<.001	3	4
BONE	DPH5 →	+0.545	+1.115	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIPIN by Atrial cardiac muscle tissue morphogenesis activity — LIVER

Explore this box plot interactively →