Cardiac muscle tissue morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac muscle tissue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG2, PKP2, and LRRC8C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle tissue morphogenesis activity versus CRYBG2 in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CRYBG2 →	+1.970	+0.799	<.001	.001	3	8
LUNG_SCLC	PKP2 →	+2.422	+0.899	<.001	.002	2	8
LUNG_NSCLC_LUAD	LRRC8C →	-0.774	-0.674	.007	.005	3	7
LUNG_NSCLC_LUAD	PRSS8 →	+2.335	+0.530	.003	.002	3	7
PANCREAS	GET3 →	-0.745	-1.073	.003	.005	3	6
STOMACH	PRR15 →	+2.819	+0.589	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055008 vs CRYBG2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →