Cardiac cell development

Across TCGA patient cohorts, RNA activity of the Cardiac cell development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO, UTRN, and PALLD, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac cell development activity versus SYNPO in HNSC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO →	+0.425	+0.057	<.001	<.001	3	10
BRCA	UTRN →	+0.318	+0.044	<.001	<.001	3	10
UCEC	PALLD →	+0.682	+0.054	<.001	<.001	3	10
HNSC	SYNPO2 →	+0.980	+0.065	<.001	<.001	3	9
BRCA	TLN2 →	+0.699	+0.054	<.001	<.001	3	9
OV	TNS2_S120 →	+0.607	+0.030	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055006 vs SYNPO — HNSC

Explore this scatter interactively →