Cardiac cell development

Across TCGA patient cohorts, RNA activity of the Cardiac cell development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, EDNRA, and LINC00702, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac cell development activity versus TIMP3 in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP3 →	+1.471	+0.400	<.001	<.001	3	8
LSCC	EDNRA →	+1.395	+0.202	<.001	<.001	3	8
CCRCC	LINC00702 →	+0.696	+0.447	<.001	<.001	3	8
CCRCC	DCN →	+1.856	+0.365	<.001	.005	3	7
BRCA	TSHZ3 →	+0.772	+0.353	<.001	<.001	3	7
LSCC	CALD1 →	+0.761	+0.248	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0055006 vs TIMP3 — BRCA

Explore this scatter interactively →