Cellular glucuronidation

pathway activity — cross-omics
GO:0052695Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cellular glucuronidation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, FES, and HNRNPR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMAIF1 →-0.662-0.118<.001<.00136
GBMFES →-0.454-0.123<.001<.00136
GBMHNRNPR →+0.277+0.088<.001<.00135
LSCCMICAL1 →-0.318-0.177<.001<.00135
GBMGMFG →-0.571-0.106<.001<.00135
LSCCAOX1 →-0.423-0.195<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration