Cellular glucuronidation

pathway activity — cross-omics
GO:0052695Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cellular glucuronidation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH3A1, NECAB2, and EDIL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCALDH3A1 →+2.831+0.611<.001<.00134
GBMNECAB2 →+0.851+0.237.001<.00134
GBMEDIL3 →+1.120+0.229<.001<.00134
GBMMIR4427 →+1.152+0.233<.001<.00134
CCRCCRNU2-29P →+0.151+0.132.001.00933
CCRCCRHEBP3 →+0.845+0.180<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration