Alditol phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Alditol phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD2, TOMM70, and SMIM4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alditol phosphate metabolic process activity versus GPD2 in CNS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPD2 →	+1.339	+1.014	.001	.001	2	6
OESOPHAGUS	TOMM70 →	-0.612	-0.631	<.001	.004	3	3
OESOPHAGUS	SMIM4 →	-1.292	-0.823	.004	.006	3	3
KIDNEY	TIMM50 →	+0.473	+1.402	<.001	.001	3	3
KIDNEY	SORD →	+0.889	+1.402	.006	.001	3	3
BREAST	ARHGAP22 →	-1.540	-0.432	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0052646 vs GPD2 — CNS

Explore this scatter interactively →