Positive regulation of attachment of spindle microtubules to kinetochore

Across TCGA cell cohorts, RNA activity of the Positive regulation of attachment of spindle microtubules to kinetochore pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMO5, CLIC1, and COG5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of attachment of spindle microtubules to kinetochore activity versus FMO5 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FMO5 →	+1.868	+0.268	.008	.006	3	5
LUNG_NSCLC_LUAD	CLIC1 →	-0.793	-0.143	<.001	.002	3	5
LUNG_SCLC	COG5 →	-0.403	-0.131	.004	.004	3	5
LUNG_SCLC	RCC2 →	+0.638	+0.186	<.001	<.001	3	5
OVARY	SGSH →	-0.707	-0.108	.003	.005	3	5
SOFT_TISSUE	LMTK2 →	-0.631	-0.078	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051987 vs FMO5 — STOMACH

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