Positive regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AREG, SMC2, and PTTG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AREG grouped by Positive regulation of chromosome segregation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AREG →	+4.602	+0.183	<.001	.007	3	5
PANCREAS	SMC2 →	-1.205	-0.169	<.001	.001	3	5
SOFT_TISSUE	PTTG1 →	-1.041	-0.296	.007	.001	3	5
SOFT_TISSUE	IGFL2 →	+4.235	+0.275	.009	<.001	3	5
OVARY	ANXA9 →	+1.714	+0.123	<.001	.009	3	4
URINARY_TRACT	LRRC58 →	-0.927	-0.174	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AREG by Positive regulation of chromosome segregation activity — STOMACH

Explore this box plot interactively →