Positive regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHAF1A, UHRF1, and STMN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromosome segregation activity versus CHAF1A in STOMACH (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CHAF1A →	+1.309	+0.243	<.001	<.001	3	9
BLOOD_Leukemia	UHRF1 →	+1.364	+0.179	<.001	<.001	3	9
BLOOD_Leukemia	STMN1 →	+1.277	+0.223	<.001	<.001	3	9
LIVER	NSD2 →	+1.128	+0.346	.009	.001	3	8
BLOOD_Myeloma	CCDC77 →	+0.922	+0.377	.008	.008	2	8
OVARY	SF3A2 →	+0.887	+0.240	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051984 vs CHAF1A — STOMACH

Explore this scatter interactively →