Regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGDS, PRKRA, and JOSD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TGDS grouped by Regulation of chromosome segregation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TGDS →	-0.509	-0.148	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PRKRA →	-0.633	-0.130	.007	.008	3	4
BLOOD_Leukemia	JOSD2 →	+1.179	+0.141	.003	.007	3	4
LARGE_INTESTINE	COPS5 →	-0.541	-0.160	.001	.009	3	4
LUNG_NSCLC_LUAD	UCK2 →	-0.602	-0.106	.003	.005	2	5
BLOOD_Lymphoma	APIP →	-0.870	-0.293	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TGDS by Regulation of chromosome segregation activity — BREAST

Explore this box plot interactively →