Regulation of chromosome segregation

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome segregation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR173, STMN1, and TMEM214, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome segregation activity versus GPR173 in OVARY (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPR173 →	+1.435	+0.478	<.001	.009	3	4
BLOOD_Leukemia	STMN1 →	+1.234	+0.241	<.001	.002	3	4
BLOOD_Lymphoma	TMEM214 →	-0.661	-0.127	.001	.003	3	4
BLOOD_Lymphoma	FAM117B →	+0.838	+0.171	<.001	<.001	3	4
BLOOD_Lymphoma	ITGAX →	-2.658	-0.161	.008	.003	3	4
BLOOD_Leukemia	TMSB15B →	+2.086	+0.256	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051983 vs GPR173 — OVARY

Explore this scatter interactively →