Positive regulation of transmission of nerve impulse

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP16, TMLHE, and FAM76A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP16 grouped by Positive regulation of transmission of nerve impulse-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PARP16 →	+1.251	+1.204	.003	.004	3	4
BLOOD_Leukemia	TMLHE →	+0.717	+1.200	.007	.003	3	4
BLOOD_Leukemia	FAM76A →	+0.932	+1.497	<.001	<.001	3	4
STOMACH	SMURF1 →	+0.910	+0.217	.002	.006	3	4
PANCREAS	PALLD →	+1.687	+1.071	<.001	.001	3	3
OVARY	ANKRD46 →	-0.816	-1.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP16 by Positive regulation of transmission of nerve impulse activity — BLOOD_Leukemia

Explore this box plot interactively →