Regulation of transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Regulation of transmission of nerve impulse pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EGFR_T693, DNMT3A_S105, and ABT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmission of nerve impulse activity versus EGFR_T693 in LUAD (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EGFR_T693 →	+0.639	+0.105	.002	.003	3	6
LSCC	DNMT3A_S105 →	-0.432	-0.084	.004	.001	3	5
UCEC	ABT1 →	-0.319	-0.097	.002	.001	3	5
CCRCC	SCAF1_S548 →	-0.184	-0.054	.001	.002	3	5
OV	SAP130 →	-0.187	-0.054	.006	.004	3	4
OV	TOP1 →	-0.345	-0.053	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051969 vs EGFR_T693 — LUAD

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