Regulation of transmission of nerve impulse

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of transmission of nerve impulse pathway differs between tumor and matched normal tissue in 16 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LIHC and UCEC, show the opposite pattern, with lower activity in tumor tissue.

LIHC, LUAD, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Female	III,IV	−0.198	<.001	8	view →
LUAD	Male	All	+0.091	<.001	8	view →
KICH	All	All	+0.111	<.001	6	view →
BLCA	All	III,IV	+0.094	<.001	6	view →
COAD	All	II,III,IV	+0.080	<.001	6	view →
ESCA	All	II,III,IV	+0.224	.006	4	view →
KIRP	All	IV	+0.107	.001	4	view →
THCA	Female	All	+0.059	<.001	4	view →
UCEC	All	III,IV	−0.051	.012	4	view →
STAD	All	All	+0.060	.007	3	view →
LUSC	All	All	+0.051	.001	3	view →
READ	Female	All	+0.155	.007	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 16 lineages.

GO:0051969–LIHC

Open the LIHC breakdown →