Regulation of transmission of nerve impulse

Across TCGA patient cohorts, RNA activity of the Regulation of transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, PAK5, and APLP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of transmission of nerve impulse activity versus ITGA2 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA2 →	+0.973	+0.229	<.001	<.001	3	5
GBM	PAK5 →	+0.729	+0.302	<.001	<.001	3	3
GBM	APLP1 →	+0.846	+0.258	<.001	.002	3	3
GBM	ATRNL1 →	+1.840	+0.402	<.001	<.001	3	3
GBM	NECTIN1 →	+0.589	+0.245	<.001	<.001	3	3
GBM	GDAP1L1 →	+1.002	+0.314	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051969 vs ITGA2 — BRCA

Explore this scatter interactively →