Regulation of transmission of nerve impulse

Across TCGA cell cohorts, RNA activity of the Regulation of transmission of nerve impulse pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHLD2, SMAGP, and PSTPIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHLD2 grouped by Regulation of transmission of nerve impulse-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SHLD2 →	-0.633	-1.425	.007	.003	3	4
BLOOD_Leukemia	SMAGP →	-2.371	-1.187	<.001	<.001	3	4
SOFT_TISSUE	PSTPIP2 →	-2.134	-1.041	<.001	.008	3	4
SKIN	TREML2 →	-0.047	-0.847	.001	.001	3	4
BLOOD_Lymphoma	IQSEC1 →	+2.715	+1.974	.001	<.001	3	4
LARGE_INTESTINE	NPNT →	-2.676	-1.079	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHLD2 by Regulation of transmission of nerve impulse activity — LIVER

Explore this box plot interactively →