Regulation of transmission of nerve impulse

Across TCGA cell cohorts, RNA activity of the Regulation of transmission of nerve impulse pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are AZD3514, Ruxolitinib, and I-CBP112, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AZD3514 grouped by Regulation of transmission of nerve impulse-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AZD3514 →	-0.600	-0.324	.026	.032	3	3
LUNG_SCLC	Ruxolitinib →	-0.667	-0.355	.026	.009	3	3
LUNG_SCLC	I-CBP112 →	-0.464	-0.443	.001	.002	3	3
LUNG_SCLC	WIKI4 →	-0.643	-0.388	<.001	.016	3	3
LUNG_SCLC	KIN001-236 →	-0.645	-0.359	.002	.017	3	3
LUNG_SCLC	KIN001-244 →	-0.495	-0.468	.014	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD3514 by Regulation of transmission of nerve impulse activity — LUNG_SCLC

Explore this box plot interactively →