Positive regulation of nervous system development

Across TCGA cell cohorts, RNA activity of the Positive regulation of nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, SAMD1, and SPRED3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGALS1 grouped by Positive regulation of nervous system development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LGALS1 →	-3.400	-0.118	.002	.009	3	5
LARGE_INTESTINE	SAMD1 →	+0.747	+0.149	.002	.001	3	4
BONE	SPRED3 →	-1.006	-0.215	.005	.003	3	4
BONE	POLE →	+1.200	+0.212	.003	.003	3	4
SOFT_TISSUE	SERGEF →	-0.659	-0.186	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PRRC2A →	-0.690	-0.183	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGALS1 by Positive regulation of nervous system development activity — STOMACH

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