Positive regulation of nervous system development

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of nervous system development pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 288 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Positive regulation of nervous system development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

MESO, STAD, and HNSC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.391	0.625	<.001	114	view →
STAD	DFS	Quartile	II,III,IV	0.344	0.630	.007	71	view →
HNSC	DFS	Tertile	IV	0.439	0.218	<.001	68	view →
KIRC	OS	Median	All	0.536	0.704	<.001	60	view →
UCS	OS	Tertile	II,III,IV	0.736	0.219	.003	46	view →
BLCA	DFS	Tertile	All	0.129	0.446	.002	30	view →
ESCA	DFS	Median	III,IV	0.479	0.252	.026	18	view →
SKCM	OS	Quartile	II,III,IV	0.467	0.180	.003	18	view →
THCA	DFS	Median	All	0.899	0.770	.015	15	view →
ACC	OS	Quartile	All	0.285	0.853	<.001	8	view →
LIHC	DFS	Quartile	All	0.332	0.649	.005	7	view →
PRAD	OS	Median	All	1.000	0.979	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0051962–MESO (OS)

Open the MESO breakdown →