Positive regulation of nervous system development

Across TCGA cell cohorts, RNA activity of the Positive regulation of nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFB2M, GNL3, and RSL1D1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nervous system development activity versus TFB2M in OESOPHAGUS (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TFB2M →	-0.666	-0.173	.009	.001	3	5
LIVER	GNL3 →	-0.881	-0.356	.002	<.001	3	5
SOFT_TISSUE	RSL1D1 →	-0.965	-0.300	.003	.002	3	5
PANCREAS	SCLY →	-1.014	-0.191	.002	.002	2	6
LARGE_INTESTINE	ARHGAP29 →	+1.786	+0.196	<.001	<.001	3	5
LARGE_INTESTINE	DHX33 →	-0.678	-0.234	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051962 vs TFB2M — OESOPHAGUS

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