Negative regulation of nervous system development

Across TCGA patient cohorts, RNA activity of the Negative regulation of nervous system development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRDL2, RNF125, and SPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nervous system development activity versus CHRDL2 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHRDL2 →	-1.063	-0.333	.002	.001	3	5
LSCC	RNF125 →	-0.777	-1.141	<.001	.002	3	5
HNSC	SPP1 →	+2.218	+0.339	.002	.003	3	4
HNSC	CLNK →	-0.837	-0.345	.002	<.001	3	4
LSCC	SLAMF6 →	-1.530	-1.141	<.001	.002	3	4
PDAC	CCR4 →	-0.924	-0.439	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051961 vs CHRDL2 — HNSC

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