Positive regulation of amino acid transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAFA2, PCCB, and CCT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amino acid transport activity versus TAFA2 in LUNG_NSCLC_LUSC (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TAFA2 →	-0.550	-0.345	.001	<.001	3	6
LUNG_NSCLC_LUAD	PCCB →	-0.705	-0.220	.003	.002	3	6
KIDNEY	CCT2 →	-0.695	-0.204	.003	.002	3	5
BREAST	TOMM70 →	-0.598	-0.285	.001	.001	2	6
BREAST	AFAP1L2 →	+2.308	+0.513	<.001	.005	3	5
SKIN	AVPI1 →	+1.629	+0.212	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051957 vs TAFA2 — LUNG_NSCLC_LUSC

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