Regulation of amino acid transport

Across TCGA cell cohorts, RNA activity of the Regulation of amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGN3, RHOBTB3, and RPL14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMGN3 grouped by Regulation of amino acid transport-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HMGN3 →	+0.467	+1.580	.002	<.001	2	5
OVARY	RHOBTB3 →	+2.044	+0.693	.005	.007	3	4
OVARY	RPL14 →	-1.004	-1.047	<.001	.002	3	4
OVARY	COL9A2 →	+2.293	+1.188	.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC25A16 →	+0.811	+0.965	<.001	<.001	3	3
LUNG_SCLC	TMEM183A →	+0.487	+0.891	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMGN3 by Regulation of amino acid transport activity — URINARY_TRACT

Explore this box plot interactively →