Negative regulation of amine transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of amine transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAMP2, RETREG2, and ZNF837, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCAMP2 grouped by Negative regulation of amine transport-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCAMP2 →	+0.778	+0.934	.007	.005	3	5
KIDNEY	RETREG2 →	+0.707	+0.874	.002	.008	3	4
KIDNEY	ZNF837 →	+0.482	+0.876	.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	ZSCAN31 →	+2.379	+0.601	<.001	<.001	3	4
LARGE_INTESTINE	FBXW4 →	+1.056	+0.948	<.001	.003	3	4
LUNG_NSCLC_LUAD	DAP →	+0.754	+0.845	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCAMP2 by Negative regulation of amine transport activity — LARGE_INTESTINE

Explore this box plot interactively →