L-glutamate import

Across TCGA patient cohorts, RNA activity of the L-glutamate import pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCLAF1_S198, GYPA_S148, and LSP1_S177, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import activity versus BCLAF1_S198 in COAD (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BCLAF1_S198 →	+0.499	+0.812	<.001	<.001	3	3
LSCC	GYPA_S148 →	-2.037	-1.357	<.001	<.001	3	3
GBM	LSP1_S177 →	-0.990	-0.449	<.001	<.001	3	3
GBM	BASP1_S164 →	+1.063	+0.364	<.001	<.001	3	3
OV	DEF6_S597 →	-1.137	-0.293	.002	.008	3	3
BRCA	ENTPD5 →	+0.699	+0.639	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051938 vs BCLAF1_S198 — COAD

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