"Synaptic transmission, GABAergic"

Across TCGA patient cohorts, RNA activity of the "Synaptic transmission, GABAergic" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3D19, VCL, and KANK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Synaptic transmission, GABAergic" activity versus SH3D19 in LSCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3D19 →	-0.343	-0.051	<.001	<.001	3	5
COAD	VCL →	-0.324	-0.028	.001	<.001	3	5
LSCC	KANK2 →	-0.434	-0.057	<.001	<.001	3	5
COAD	LMOD1 →	-0.682	-0.038	<.001	<.001	3	5
BRCA	NCK2 →	-0.252	-0.038	.004	<.001	3	5
LSCC	PALM2AKAP2 →	-0.321	-0.043	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051932 vs SH3D19 — LSCC

Explore this scatter interactively →