Regulation of sensory perception

Across TCGA patient cohorts, RNA activity of the Regulation of sensory perception pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVI2B, SERPINB1, and STX11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sensory perception activity versus EVI2B in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EVI2B →	+0.297	+0.039	.008	.006	3	7
LSCC	SERPINB1 →	+0.284	+0.045	.002	<.001	3	6
LSCC	STX11 →	+0.308	+0.061	.001	<.001	3	6
GBM	GIMAP8 →	+0.416	+0.056	.002	.001	3	6
GBM	CRYBG3 →	+0.307	+0.087	<.001	<.001	3	6
GBM	FKBP15_S1012 →	+0.433	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051931 vs EVI2B — GBM

Explore this scatter interactively →