Regulation of sensory perception

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of sensory perception pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 18 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of sensory perception pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CHOL and HNSC, show the opposite pattern, with higher activity associated with better survival.

UVM, UCS, and THYM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.410	0.755	<.001	87	view →
UCS	OS	Quartile	II,III,IV	0.294	0.857	.002	32	view →
THYM	DFS	Quartile	All	0.526	0.889	.004	29	view →
KIRP	OS	Quartile	II,III,IV	0.271	0.776	.004	23	view →
STAD	OS	Median	All	0.382	0.639	.009	21	view →
LAML	DFS	Quartile	All	0.291	0.605	.002	18	view →
LUSC	OS	Quartile	All	0.564	0.727	.003	17	view →
MESO	OS	Quartile	All	0.237	0.527	.005	16	view →
DLBC	DFS	Quartile	III,IV	0.074	1.000	.017	13	view →
TGCT	DFS	Tertile	All	0.712	0.906	.025	12	view →
BRCA	OS	Tertile	IV	0.320	0.710	.036	12	view →
CHOL	OS	Median	II,III,IV	0.751	0.322	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0051931–UVM (DFS)

Open the UVM breakdown →