Regulation of sensory perception

Across TCGA cell cohorts, RNA activity of the Regulation of sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM12, PPM1G, and SLC5A6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM12 grouped by Regulation of sensory perception-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RBM12 →	+0.929	+1.279	<.001	.005	3	6
CNS	PPM1G →	+0.352	+0.702	.006	.005	3	5
CNS	SLC5A6 →	+0.622	+0.722	<.001	.004	3	4
SOFT_TISSUE	COMMD9 →	+0.560	+1.091	.005	.007	3	3
SOFT_TISSUE	SMIM22 →	+0.422	+1.424	<.001	.004	3	3
KIDNEY	ZNF142 →	+0.719	+1.008	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM12 by Regulation of sensory perception activity — BONE

Explore this box plot interactively →