Regulation of sensory perception

Across TCGA cell cohorts, RNA activity of the Regulation of sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMS3, PPARG, and CX3CL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sensory perception activity versus LIMS3 in OVARY (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LIMS3 →	-1.941	-1.614	.001	.001	3	3
OVARY	PPARG →	+3.442	+1.230	<.001	.003	3	3
OVARY	CX3CL1 →	-3.814	-1.230	<.001	.003	3	3
BLOOD_Lymphoma	MASP2 →	+0.500	+0.173	.002	.005	3	2
BREAST	ADHFE1 →	-1.341	-1.783	<.001	<.001	3	2
BREAST	U2SURP →	-0.330	-1.718	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051931 vs LIMS3 — OVARY

Explore this scatter interactively →