Positive regulation of calcium ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5, CCL4, and APOL3, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport activity versus CCR5 in SCLC (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CCR5 →	+2.412	+0.105	<.001	<.001	3	33
CHOL	CCL4 →	+2.162	+0.035	<.001	<.001	3	33
SCLC	APOL3 →	+1.920	+0.113	<.001	<.001	3	32
DLBC	LILRB2 →	+1.908	+0.031	<.001	.002	3	32
BLCA	FCER1G →	+2.220	+0.031	<.001	<.001	3	32
BLCA	CCL3 →	+1.878	+0.030	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051928 vs CCR5 — SCLC

Explore this scatter interactively →