Positive regulation of calcium ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP25, PLEKHO2, and STK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport activity versus ARHGAP25 in HNSC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP25 →	+0.511	+0.048	<.001	<.001	3	10
GBM	PLEKHO2 →	+0.378	+0.050	<.001	<.001	3	10
LSCC	STK10 →	+0.346	+0.038	<.001	<.001	3	9
GBM	VAV1 →	+0.455	+0.051	<.001	<.001	3	9
UCEC	WARS1 →	+0.674	+0.034	<.001	<.001	3	9
OV	WIPF1 →	+0.391	+0.029	.009	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051928 vs ARHGAP25 — HNSC

Explore this scatter interactively →