Positive regulation of calcium ion transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, ASPA, and ABCA8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium ion transport activity versus PDE1A in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDE1A →	+0.727	+0.364	<.001	<.001	3	7
UCEC	ASPA →	+0.716	+0.262	<.001	<.001	3	6
UCEC	ABCA8 →	+1.177	+0.234	<.001	<.001	3	6
HNSC	PDLIM3 →	+1.623	+0.203	<.001	.002	3	6
OV	MEOX2 →	+0.988	+0.206	<.001	<.001	3	6
OV	KLF2 →	+1.086	+0.260	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051928 vs PDE1A — BRCA

Explore this scatter interactively →