Positive regulation of calcium ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POM121L2, CASR, and NAT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POM121L2 grouped by Positive regulation of calcium ion transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	POM121L2 →	-0.195	-0.228	.009	<.001	3	7
LUNG_SCLC	CASR →	-0.249	-0.285	.008	.001	2	6
BREAST	NAT1 →	-0.228	-0.329	<.001	.006	3	5
LUNG_SCLC	PSG8 →	+0.210	+0.260	<.001	.002	3	5
LUNG_SCLC	GLB1L2 →	-0.274	-0.218	.003	.003	3	5
BREAST	NUPR2 →	-0.287	-0.219	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POM121L2 by Positive regulation of calcium ion transport activity — BREAST

Explore this box plot interactively →