Positive regulation of calcium ion transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are U2AF1L5, H4C15, and ATP13A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, U2AF1L5 grouped by Positive regulation of calcium ion transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	U2AF1L5 →	+0.506	+0.202	.001	.007	3	5
SKIN	H4C15 →	-0.858	-0.758	.003	.002	3	4
BLOOD_Lymphoma	ATP13A1 →	-1.867	-0.206	.002	.004	3	4
BLOOD_Myeloma	CENPI →	+1.075	+1.369	.003	.002	3	4
BLOOD_Myeloma	UPF2 →	+0.811	+1.077	.004	.002	3	4
BLOOD_Myeloma	TRMT2B →	+0.960	+1.311	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

U2AF1L5 by Positive regulation of calcium ion transport activity — LIVER

Explore this box plot interactively →