Establishment of pigment granule localization

Across TCGA patient cohorts, RNA activity of the Establishment of pigment granule localization pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1109, KIAA0825, and RBL2, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of pigment granule localization activity versus KIAA1109 in DLBC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	KIAA1109 →	+1.264	+0.071	<.001	<.001	2	32
THYM	KIAA0825 →	+0.450	+0.048	<.001	<.001	3	31
DLBC	RBL2 →	+1.368	+0.050	<.001	.002	2	31
UCEC	TEX9 →	+0.722	+0.032	<.001	<.001	3	30
UVM	ALG13-AS1 →	+1.195	+0.039	<.001	<.001	3	30
THYM	PRPF40B →	+1.110	+0.047	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051905 vs KIAA1109 — DLBC

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