Establishment of pigment granule localization

Across TCGA patient cohorts, RNA activity of the Establishment of pigment granule localization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIFAP3, TTC26, and SHROOM2_S779, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of pigment granule localization activity versus KIFAP3 in CCRCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KIFAP3 →	+0.247	+0.054	<.001	<.001	3	5
LSCC	TTC26 →	+0.268	+0.032	.003	.005	3	5
LUAD	SHROOM2_S779 →	+0.569	+0.028	<.001	<.001	3	5
BRCA	KIF3B →	+0.305	+0.037	<.001	<.001	3	4
GBM	LZTS1_S233 →	+0.667	+0.040	<.001	<.001	3	4
COAD	PDCD6IP →	-0.204	-0.025	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051905 vs KIFAP3 — CCRCC

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