Establishment of pigment granule localization

Across TCGA cell cohorts, RNA activity of the Establishment of pigment granule localization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNRPA, RAB27A, and HFM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of pigment granule localization activity versus SNRPA in BREAST (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SNRPA →	-0.585	-0.866	.002	.003	2	8
SKIN	RAB27A →	+1.695	+0.322	.003	.003	3	6
OESOPHAGUS	HFM1 →	-0.402	-0.718	.005	.002	3	6
BLOOD_Myeloma	CELSR2 →	-2.206	-1.303	.006	.002	3	5
BLOOD_Leukemia	SLC22A4 →	+1.354	+0.715	<.001	<.001	3	5
LARGE_INTESTINE	DHODH →	-0.560	-0.639	.005	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051905 vs SNRPA — BREAST

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