Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF699, RAB11FIP4, and RAB40C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction activity versus ZNF699 in CNS (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF699 →	+0.994	+0.156	.003	.006	3	5
LIVER	RAB11FIP4 →	-3.844	-0.297	<.001	.001	3	5
LUNG_NSCLC_LUAD	RAB40C →	-0.865	-0.159	<.001	<.001	3	5
SOFT_TISSUE	ZNF263 →	-0.761	-0.276	.002	.005	3	5
LARGE_INTESTINE	SORBS1 →	-2.206	-0.198	<.001	.005	3	5
CNS	PMP22 →	+2.089	+0.224	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051897 vs ZNF699 — CNS

Explore this scatter interactively →